Contrary to what your mother may have told you, it’s not what you’re eating that causes acne. Acne has a strong genetic component, exacerbated by hormonal changes (most women already know this!); stress associated with school, jobs and starting families, and sometimes-poor skin care regimens. Everyone knows that acne affects teenagers, but most people do not realize that young adults in their 20´s and 30´s are more likely to develop acne than their teen counterparts.
NOT ALL ACNE IS CREATED EQUAL
There are different types of acne lesions as well as grades of acne severity. Treatment is based upon these possible combinations.
Types of acneiform lesions
· Open Comedone (aka the blackhead)
· Inflamed Papule
· Pustule (aka closed comedone)
· Painful Nodular Cysts
Doctors perform acne grading to help track improvement (or lack thereof) to therapy. Grade 1 is the mildest, with very few lesions. This continues up through grade 4, acne that has the most significant surface coverage.
When a patient presents in my office, I quickly evaluate the overall severity of the acne (the grade) and the types of lesions present. Every doctor has their favorite combinations of treatments that have been successful for their patients, so what I am about to share with you are regimens that I tend to favor. I allow 6-8 weeks for any therapy regimen to show significant (I didn’t say miraculous) improvement. If a patient does not demonstrate this, I will often change their medications. If you have been on the same medicines for a year and you are still breaking out, discuss this with your doctor!
Very mild, grade 1 acne, composed of small, superficial lesions, such as blackheads and pustules often responds well to topical therapy. My favorite prescription topical that shows consistent resolutions of blackheads continues to be Retin A .025% cream. Frequently, patients will tell me they have used Retin A in the past and have experienced quite a bit of irritation. Almost everyone can use Retin A if used properly.
I tell my patients to wait 30 minutes after washing before applying a pea-size amount of Retin A to the face. I also tell them to apply it only every other night when starting out. This minimizes the dryness. If the patient experiences anything more than some mild white flaking, they should back off to every third, fourth, or fifth nights, etc. until they can tolerate its use.
For patients with incredibly oily skin or for those who have innumerable stubborn blackheads, I have been very pleased with the Tazorac Gel that comes in 2 strengths, 0.05 and 0.01%. It is used in the same manner as Retin A or other similar derivatives.
Prescription Therapy For Acne Currently On The U.S. Market*
PILLS
Used to kill the bacteria P. acnes that causes acne flares as well as act as anti-inflammatory agents, reducing the size of acne lesions and helping prevent outbreaks altogether. Spironolactone works for those women with hormonal influences causing acne. BCPs again work at the hormonal level. Accutane works to correctly form the oil glands whose linings are improperly forming, and is the closest to a “cure” we have for acne.
· Tetracycline
· Minocycline
· Doxycyline
· Erythromycin
· Bactrim (Sulfa)
· Accutane
· Birth Control Pills (Ortho Tricyclen)
· Spironolactone
DIETARY SUPPLEMENTS
VitaMedica Healthy Skin is a nutritional supplement that provides internal skin care by enhancing the body´s natural systems for repairing, cleansing and healing. The supplement is intended as an adjunctive therapy to the topical products and/or treatments that skin care professionals recommend for acne patients.
Many topical treatments for the care of acne and inflammatory disorders of the skin are currently available. While effective, these regimens contain products that produce an action primarily on the outer layer of the skin. Although the topical approach represents the foundation of good skin care, it also makes sense to address what is going on internally. That´s because what you put inside your body may be just as important as what you apply externally.
VitaMedica Healthy Skin is indicated for patients with mild to moderate acne. The product is suitable for patients 12 years or older. This nutraceutical is ideal for individuals who do not eat a well-balanced diet on a consistent basis. Certain individuals should seek the advice of their doctor before beginning the program particularly diabetics, pregnant or lactating women. Healthy Skin Formula contains Vitamin A. If you are presently taking Accutane® (isotretinoin) for the treatment of acne, please refrain from taking HEALTHY SKIN FORMULA until the end of the treatment cycle.
TOPICALS
Topical Vitamin A Derivatives
Used to remove blackheads, dry up excess oils and smooth out bumpy acne.
· Tretinoins (Retin A, Avita)
· Tazarotene (Tazorac)
· Adapalene (Differin)
Topical Antibiotics
Used to kill of P. acnes, the bacteria responsible for flaring acne outbreaks.
· Erythromycin (Erycette, Emgel)
· Clindamycin (Cleocin T)
· Azelex
· Benzoyl Peroxide (BPO)
· Benzamycin (a combination of BPO and Erythromycin)
· Clinac BP (a combination of Clinac O.C. and Benzoyl Peroxide)
· Metronidazole (MetroGel/Lotion/Cream & Noritate)
· Plexion Lotion & Cleanser (Sulfa based)
INJECTABLES
The stray cyst can always rapidly be resolved with a small shot of steroid solution known as Kenalog (triamcinolone). The plus side to this is the rapid resolution for those "little emergency" situations like weddings, prom, etc. The draw back is that this is simply not the way to treat widespread recurrent acne. Nor is it pleasant should you experience the atypical "sink" spot where fat atrophy has taken place as a side effect from the shot. Fortunately this is unusual and fills in over several months.
DRYING AGENTS
Drying agents help reduce oils and often contain ingredients to help unplug pores otherwise known as keratolytic activity. Many OTC products contain these 2 activities in addition to some antibacterial properties thanks to Benzoyl Peroxide.
· Sulfur (Sulfacet R)
*This list is not meant to be fully comprehensive.
Non Prescription Therapy Options For Acne*
· Salicylic Acid (a.k.a. Beta Hydroxy Acid)
· Glycolic Acid
· Oil-Absorbers
· Oil-Absorbing Therapeutic Masques
· Combination Products (Peter Thomas Roth Max BPO Gel 10%,
· BPO
· Drying Agents/Keratolytics
· "Scar" therapy
· Discoloration therapy
*This list is not meant to be fully comprehensive.
While there is no single perfect prescription item in the treatment of acne, I still find topical Azelex 20% Cream to be a personal favorite. This medication is great for treating small inflammatory papules and pustules, and also works well for folliculitis and "hair bumps". This product works well in conjunction with Retin A. It is applied twice daily (ideally morning and dinner time), while the Retin A is applied by itself at bedtime.
A few tips when treating acne.
· Blackheads often require some form of prescription topical vitamin A product for eradication. Several agents have been clinically proven to target a variety of factors that contribute to the formation of a blackhead while improving the appearance of pores. It can be used solo or in conjunction with a prescription regimen depending upon the severity of the problem.
· Cysts respond best to pill therapy.
· A corollary: If you’re under 13, nursing or pregnant, tetracycline based medications are off limits as they can permanently discolor the tooth enamel. If you really need oral medication, usually it’s limited to Erythromycin.
· Consistency of treatment is your best asset when trying to get results. Don’t pick, it can lead to scar formation.
· Allow at least 6-8 weeks for every new therapy to kick in before giving up on it.
· Don’t scrub your face or get facials if you’re acne prone. This simply traumatizes the glands and leads to further flare-ups.
· Keep your bangs off your forehead and your hands off your face. This deposits excess oils that can further clog pores.
· Avoid the use of heavy skin care products like cocoa butter, they will smother the skin and flare your acne.
· Don’t apply your acne creams/lotions, etc. heavily like a masque (unless it is one). There is no reason that your cream needs to be seen in order to work.
· Remove your make-up when you’re at home. Let your skin breathe!
Skin care for those who are acne prone can be enhanced by the use of high potency glycolic acids. "Medical grade" should provide at a minimum level of 8%, preferably 12% or higher. Neostrata line of acne agents contains 12% glycolic acid, can be used for removing excess oils and surface debris, thus unclogging pores. For anyone concerned about rejuvenation and acne, Neostrata has a bevy of antioxidants combined with even higher levels of glycolic acid (15% and 20%, respectively), providing an enhanced cleansing experience.
The application of a topical glycolic acid gel or lotion such as Neostrata can also be used in conjunction with other topicals such as Azelex at the same time, it helps to draw the medication in deeper and become more effective.
Many times, patients will also have a great number of inflammatory papules and/or cystic lesions. In this case, oral medication is needed in addition to topical therapy for effective resolution. The tetracycline family is the most effective. Regular tetracycline (aka sumycin), is used in doses of 500mg twice daily. Minocin is a more aggressive member of this antibiotic family. It also is much more expensive. I save this for patients who show no response to tetracycline, or patients with mostly cystic acne. Doxycycline is similar to minocycline, however, I have not had nearly the response rate to this medication as I have to Minocin so I tend to avoid its use. Erythromycin is not nearly as effective for treating acne and tends to cause significant stomach upset. I save this for patients who are younger than 13 (tetracycline products will discolor dental enamel in this age bracket) or for patients who for some reason cannot take tetracycline. If you are on Erythromycin, take it on a full stomach you’ll be more likely to tolerate it.
Regardless of which antibiotic you might be on, here are some things to keep in mind. After you’ve cleared in let’s say 8 weeks, that doesn’t mean you suddenly go off the medication like you have had a sinus infection. If you do, odds are you are going to break out again. Once I have found the best mix of medications that clears a patient, I usually keep them on the same routine for another 3 months. At that time, assuming all is well, I will start to slowly wean them off their oral prescription antibiotics if at all possible. If there is a flare, I go back to the dose before that kept them clear. Some patients come off the meds altogether (this is rare), most are able to take the medicine less frequently (timing will vary with the patient) and a few won’t be able to decrease their dosage whatsoever.
Unfortunately, I still come across many first time acne patients who have very severe cystic acne. These are the grade 4 cystic acne patients for whom aggressive treatment is required right away. Accutane has been a blessing for these patients. Accutane is a drug to be taken seriously. It is the closest drug we have to an acne "cure", however, it can have potential side effects. For this reason it is not offered to patients with mild acne. Occasionally, I will have a patient with significant non-cystic acne unresponsive to accepted aggressive therapy who may be placed on Accutane. Pregnancy must be avoided while on Accutane as well as for 1 month after discontinuing the drug due to the risk of birth defects. It is important to understand that the medication does NOT affect ovaries, eggs or sperm. Only a developing fetus is at risk. Treatment is for only 5 months and has repeatedly shown great results. While on Accutane, blood work is done for screening, every 2 weeks for the first month of use and monthly for the final 4 months of use. This is to monitor potential problems with blood counts, liver and kidney function as well as monitor triglyceride levels that can skyrocket during Accutane use.
Two product candidates in the acne pipeline under study include topical versions of oral medications that have been used to treat cystic acne. Topical Accutane is being used in Canada and Europe. I have had some patients present who have been given "home made" forms of this product which consisted of their pharmacist poking holes in the Accutane capsule and mixing it into a cream base. So far they have reported all it did was locally irritate and dry the skin without helping clear the acne lesions. It remains unclear whether a consistent formulation marketed after FDA approval would be more beneficial. Another medication called Dapsone used to be prescribed for severe cystic acne before the availability of oral Accutane. Dapsone continues to be used in dermatology mainly in the treatment of certain blistering disorders. So far I have heard very little about early study results of its topical use for acne therapy.
Foot Loose and Oil-Free
Finally, it is necessary to avoid the use of routine skin care products that might exacerbate or cause acne. Typically dermatologists try to recommend oil free products right away to their acne patients. Another term for these items is non-comedogenic. Products such as Neostrata are often recommended as appropriate for acne prone patients without the concerns of causing further acne flares. It is important not to dry out your skin in your enthusiasm to try to clear your face. It is natural to want to repeatedly use a helpful item or try one that is quite strong to help speed up the healing process. But overly dry skin or red, irritated, inflamed skin is not meant to be the end point. There are some acne patients who have normally dry or sensitive skin despite the presence of acne. If you fall into this category, try keeping the use of drying items to a minimum. Rarely, some acne patients are unable to use any topical acne therapy as it is simply too irritating and the use of pills again becomes necessary.
Too many acne sufferers go untreated far too long. Acne can have a real impact on an individual’s self esteem. Dermatologists are specially trained to treat skin diseases including acne. We have so many effective therapies that weren’t available in the 70’s when I was growing up. I can’t emphasize enough that NO ONE needs to suffer from acne. If you have acne that doesn’t respond to over the counter treatment, please check with a board certified dermatologist in your area.
Thank you for taking the time to read through this important information. I hope you have found this article informative.
Labels: acne, acne scarring, dermatologist, dermatology, doctor, philadelphia